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SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.3
USERS' SCORE
Good
Based on 6 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
Vitamin B12 aids low back pain
Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study.
Study focuses on isolated treatment
We conducted a thorough investigation to understand whether intramuscular vitamin B12 treatment could effectively relieve low back pain. This study was designed as a double-blind, placebo-controlled trial involving 60 patients aged 18 to 65 who suffered from mechanical low back pain or sciatic neuritis. Each participant had a history of back pain lasting from six months to five years and reported significant pain intensity according to a standard scale.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
By comparing two groups—the one receiving vitamin B12 injections and the other receiving a placebo—we focused on measuring changes in pain and disability levels, as well as any changes in paracetamol consumption. What we found was quite impressive. Both groups reported decreases in pain and disability. However, those who received vitamin B12 showed significantly better results compared to the placebo group. The difference was not only notable in terms of pain relief but also in lower dependency on paracetamol for pain management.
Our findings confirm that vitamin B12 can be a safe and effective option for patients with low back pain, particularly for those who don't have any signs of nutritional deficiency. The data suggest that patients experiencing this common ailment could consider discussing vitamin B12 treatment with their healthcare provider as part of their pain management strategy.
Read More
9
Vitamin B12 reverses back pain
Progressive Decrease in Function and Ambulation Potential: A Case of Subacute Combined Degeneration.
Moderate relevance to back pain
We explored the effects of vitamin B12 treatment on a patient experiencing severe back pain, along with other symptoms associated with subacute combined degeneration (SCD) from prolonged vitamin B12 deficiency. This case involved a 49-year-old man who faced a year of worsening weakness, pain, and gait abnormalities.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Upon diagnosis, he began receiving intramuscular vitamin B12 injections. Remarkably, within weeks, we observed significant improvements in his pain levels and mobility. This underscores the importance of recognizing vitamin B12 deficiency early since it can lead to debilitating conditions but is often reversible through timely treatment.
Our findings highlight how addressing nutrient deficiencies can enhance overall health and well-being. In this specific case, vitamin B12 not only alleviated back pain but also restored functioning, improving quality of life for the patient.
Read More
7
Methylcobalamin shows pain relief potential
Methylcobalamin: a potential vitamin of pain killer.
Moderately relevant findings
We explored the potential effects of methylcobalamin, an activated form of vitamin B12, in alleviating back pain. In recent studies, this vitamin has shown promise in treating various pain conditions, including diabetic neuropathy and low back pain.
Our observations highlighted that methylcobalamin may contribute to pain relief by enhancing nerve regeneration and improving nerve conduction. Additionally, it appears to decrease ectopic discharges in sensory neurons, which could be linked to pain sensitivity.
While the findings suggest that methylcobalamin may be effective in reducing back pain, we noted that it is not clear whether the vitamin was studied as a standalone treatment. This aspect slightly limits our understanding of its true efficacy. Overall, the potential analgesic properties of methylcobalamin present an interesting area for further research and consideration in pain management strategies.
Our observations highlighted that methylcobalamin may contribute to pain relief by enhancing nerve regeneration and improving nerve conduction. Additionally, it appears to decrease ectopic discharges in sensory neurons, which could be linked to pain sensitivity.
While the findings suggest that methylcobalamin may be effective in reducing back pain, we noted that it is not clear whether the vitamin was studied as a standalone treatment. This aspect slightly limits our understanding of its true efficacy. Overall, the potential analgesic properties of methylcobalamin present an interesting area for further research and consideration in pain management strategies.
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Most Useful Reviews
9.5
Improved iron levels
After struggling with anaemia in 2018 and spending about 8000r on injections and tests, my iron level increased by just 3 units, which was disappointing. I discovered the Aicher website and ordered vitamin B12 along with iron, as B12 aids absorption. After three weeks, my results improved significantly. Additionally, the B vitamins help to decrease homocysteine levels, which is crucial for vascular health.
Read More
9.5
Numbness resolved
I developed back pain and numbness from poor posture while using my computer, which led to thoughts of surgery for my carpal tunnel syndrome. After researching, I tried vitamin B12, which gradually eased my symptoms over a month. I can hardly believe the numbness has vanished. I highly recommend this supplement to anyone with similar issues.
Read More
8.3
Bone pain disappeared
This supplement tastes like chewable tablets, and my family enjoyed it. My mother experienced a significant positive effect, as her long-standing bone pains vanished.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.3
9.5
Mannitol and vitamin B12 improve PS
Effect of Mannitol plus Vitamins B in the management of patients with piriformis syndrome.
Combination may obscure B12 effects.
We investigated the impact of a treatment combining mannitol and vitamin B on piriformis syndrome (PS), which is characterized by sciatic nerve entrapment. In a study involving 22 patients, participants received a five-day intravenous infusion of mannitol alongside a six-week regimen of vitamin B, including B1, B2, and B12.
Our observations highlighted significant improvements in clinical assessments, particularly in tenderness and pain levels assessed by various tests and scales. Notably, the Numeric Rating Scale demonstrated a marked reduction in pain at rest, at night, and during activities, which were all statistically significant. Additionally, the swelling around the sciatic nerve also showed a noteworthy decrease.
While vitamin B12 was part of this combination treatment, we must acknowledge that the study's focus on mannitol alongside the vitamins makes it challenging to isolate vitamin B12's specific effects on back pain alone.
Nevertheless, the results suggest that the combined approach might be a promising alternative for managing PS effectively.
Our observations highlighted significant improvements in clinical assessments, particularly in tenderness and pain levels assessed by various tests and scales. Notably, the Numeric Rating Scale demonstrated a marked reduction in pain at rest, at night, and during activities, which were all statistically significant. Additionally, the swelling around the sciatic nerve also showed a noteworthy decrease.
While vitamin B12 was part of this combination treatment, we must acknowledge that the study's focus on mannitol alongside the vitamins makes it challenging to isolate vitamin B12's specific effects on back pain alone.
Nevertheless, the results suggest that the combined approach might be a promising alternative for managing PS effectively.
Read More
9
Vitamin B6's role in back pain
[Shortening diclofenac therapy by B vitamins. Results of a randomized double-blind study, diclofenac 50 mg versus diclofenac 50 mg plus B vitamins, in painful spinal diseases with degenerative changes].
Limited isolated effectiveness noted
We examined a randomized double-blind study that explored the impact of adding B vitamins, specifically B1, B6, and B12, to the treatment regimen of diclofenac for patients suffering from lower back pain due to degenerative spinal conditions.
During the study, 256 individuals participated, with some receiving diclofenac alone while others were given diclofenac alongside B vitamins for a maximum of two weeks. Interestingly, those in the group taking the B vitamins reported significantly better pain relief, allowing more patients to stop treatment early due to decreased symptoms.
While we documented some side effects, they were not significantly different between the two groups. Overall, the results indicated that incorporating B vitamins can enhance the effectiveness of diclofenac therapy, potentially allowing for less reliance on this medication for pain relief.
However, it’s important to note that the specific benefits of vitamin B6 alone on back pain cannot be definitively determined from this study, as it focused on a combination of B vitamins.
During the study, 256 individuals participated, with some receiving diclofenac alone while others were given diclofenac alongside B vitamins for a maximum of two weeks. Interestingly, those in the group taking the B vitamins reported significantly better pain relief, allowing more patients to stop treatment early due to decreased symptoms.
While we documented some side effects, they were not significantly different between the two groups. Overall, the results indicated that incorporating B vitamins can enhance the effectiveness of diclofenac therapy, potentially allowing for less reliance on this medication for pain relief.
However, it’s important to note that the specific benefits of vitamin B6 alone on back pain cannot be definitively determined from this study, as it focused on a combination of B vitamins.
Read More
9
Dolo-Neurobion's effectiveness in pain
[Complaints in the lumbosacral region and their management with Dolo-Neurobion].
Moderate vitamin B6 contribution
We explored the use of Dolo-Neurobion for managing acute pain in the lumbosacral area, particularly when linked to problems in the surrounding pelvic organs. This treatment combines neurotropic vitamins B1, B6, and B12 with the analgesic metamizole, forming an interesting approach to dealing with this kind of pain.
In our evaluation involving 53 patients, we found that the overall effectiveness of Dolo-Neurobion was quite promising. The treatment initially began with injections, followed by oral doses, which showed good to excellent results in 77.4% of the patients and moderate effects in 15.1%.
While vitamin B6 plays a role as part of this combination therapy, it’s complex to isolate its specific contribution to alleviating back pain due to the presence of other active ingredients. No major side effects or intolerance were reported, making it a fairly safe option for those suffering from lumbosacral discomfort.
In our evaluation involving 53 patients, we found that the overall effectiveness of Dolo-Neurobion was quite promising. The treatment initially began with injections, followed by oral doses, which showed good to excellent results in 77.4% of the patients and moderate effects in 15.1%.
While vitamin B6 plays a role as part of this combination therapy, it’s complex to isolate its specific contribution to alleviating back pain due to the presence of other active ingredients. No major side effects or intolerance were reported, making it a fairly safe option for those suffering from lumbosacral discomfort.
Read More
9
Methotrexate reduces epidural fibrosis
Methotrexate prevents epidural fibrosis through endoplasmic reticulum stress signalling pathway.
Moderate relevance due to indirect effects
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Read More
9
Dexamethasone and B12 improve recovery
Effects of dexamethasone combined with vitamin B12 on percutaneous endoscopic interlaminar discectomy early outcomes: a randomized controlled trial.
Vitamin B12 effects are combined
We explored the effects of combining dexamethasone with vitamin B12 during epidural injections in patients undergoing a specific type of spinal surgery, known as percutaneous endoscopic interlaminar discectomy (PEID). This study aimed to determine whether this combination could alleviate low back and leg pain that often lingers after the surgery. Patients were randomly assigned to two groups: one received only the surgery (the single surgery group), while the other received the surgery along with the combined treatment of medication.
We found that patients who received the combination of dexamethasone and vitamin B12 experienced a notable reduction in early postoperative pain, which we measured using various scoring systems. Additionally, the injections appeared to decrease the levels of certain inflammatory factors in the body, suggesting a potential biological mechanism behind the relief they experienced. Early recovery metrics, like hospital stay duration and overall satisfaction, were also improved in those receiving the combined treatment.
Therefore, the results encourage considering the use of vitamin B12 along with dexamethasone for patients recovering from disc surgery, as it seems to enhance their recovery experience effectively.
We found that patients who received the combination of dexamethasone and vitamin B12 experienced a notable reduction in early postoperative pain, which we measured using various scoring systems. Additionally, the injections appeared to decrease the levels of certain inflammatory factors in the body, suggesting a potential biological mechanism behind the relief they experienced. Early recovery metrics, like hospital stay duration and overall satisfaction, were also improved in those receiving the combined treatment.
Therefore, the results encourage considering the use of vitamin B12 along with dexamethasone for patients recovering from disc surgery, as it seems to enhance their recovery experience effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Improved iron levels
After struggling with anaemia in 2018 and spending about 8000r on injections and tests, my iron level increased by just 3 units, which was disappointing. I discovered the Aicher website and ordered vitamin B12 along with iron, as B12 aids absorption. After three weeks, my results improved significantly. Additionally, the B vitamins help to decrease homocysteine levels, which is crucial for vascular health.
Read More
9.5
Numbness resolved
I developed back pain and numbness from poor posture while using my computer, which led to thoughts of surgery for my carpal tunnel syndrome. After researching, I tried vitamin B12, which gradually eased my symptoms over a month. I can hardly believe the numbness has vanished. I highly recommend this supplement to anyone with similar issues.
Read More
8.8
Reduced joint pain
My endocrinologist recommended this supplement because of elevated homocysteine levels. The vitamins were tasty and taken sublingually. To my surprise, my joint pain, especially in my back due to a herniated lumbar spine, lessened significantly. I started getting sick less often, and I’ve repurchased the vitamins for my grandson, as they truly work.
Read More
8.3
Muscle pain relief
After using this product, I noticed a significant decrease in my muscle pain.
8.3
Bone pain disappeared
This supplement tastes like chewable tablets, and my family enjoyed it. My mother experienced a significant positive effect, as her long-standing bone pains vanished.
